Protease-Activated Receptor-2 Activation in Gastric Cancer Cells Promotes Epidermal Growth Factor Receptor Trans-Activation and Proliferation
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چکیده
منابع مشابه
Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation.
Serine proteases are now considered as crucial contributors to the development of human colon cancer. We have shown recently that thrombin is a potent growth factor for colon cancer cells through activation of the aberrantly expressed protease-activated receptor 1 (PAR1). Here, we analyzed the signaling pathways downstream of PAR1 activation, which lead to colon cancer cell proliferation in HT-...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2006
ISSN: 0002-9440
DOI: 10.2353/ajpath.2006.050841